Thermoelectric Device for Iontophoresis
DOI:
https://doi.org/10.63527/1607-8829-2026-1-84-92Keywords:
iontophoresis, thermoelectrode, thermoelectric module, thermoelectric device, heat exchanger, temperature range, thermostat, cooling, heating, biological tissue, transdermal drug delivery, efficiency of therapeutic effectAbstract
A thermoelectric device has been developed for controlled temperature support of iontophoresis procedures. Its use in standard medical iontophoresis devices significantly expands their therapeutic capabilities and improves treatment comfort. The proposed device stabilies the temperature of electrodes and hydrophilic pads in the range from 15 to 45°C with high control accuracy, optimizing the transdermal drug delivery. The use of controlled heating or cooling makes it possible to influence the rate of diffusion of drugs, the permeability of biological tissues, local blood circulation and the efficiency of therapeutic effects. The use of reduced temperatures for localization of drugs in the zone of influence, reduction of inflammatory processes and increase of treatment efficiency in various pathological conditions is especially promising. The proposed thermoelectric device design utilizes Peltier modules, a heat exchange system, and automatic temperature control, ensuring stable operation in various modes. The device can be used in conjunction with standard iontophoresis devices without any design modifications. The developed thermoelectric device enables the implementation of new temperature-controlled iontophoresis modes, opening up prospects for improving the effectiveness of physiotherapy procedures and developing new medical technologies.
References
1. Smith, B. M., Draper, D. O., Hyldahl, R. D., & Rigby, J. H. (2020). Effects of ice massage prior to an iontophoresis treatment using dexamethasone sodium phosphate. Journal of Sport Rehabilitation, 30(4), 538–544. https://doi.org/10.1123/jsr.2020-0002
2. Nugroho, A. K., Li, G., Grossklaus, A., Danhof, M., & Bouwstra, J. A. (2004). Transdermal iontophoresis of rotigotine: Influence of concentration, temperature and current density in human skin in vitro. Journal of Controlled Release, 96(1), 159–167. https://doi.org/10.1016/j.jconrel.2004.01.012
3. Wang, Y., Zeng, L., Song, W., & Liu, J. (2022). Influencing factors and drug application of iontophoresis in transdermal drug delivery: An overview of recent progress. Drug Delivery and Translational Research, 12(1), 15–26. https://doi.org/10.1007/s13346-021-00898-6
4. Batheja, P., Thakur, R., & Michniak, B. (2006). Transdermal iontophoresis. Expert Opinion on Drug Delivery, 3(1), 127–138. https://doi.org/10.1517/17425247.3.1.127
5. Nair, V., Pillai, O., Poduri, R., & Panchagnula, R. (1999). Transdermal iontophoresis. Part I: Basic principles and considerations. Methods and Findings in Experimental and Clinical Pharmacology, 21(2), 139–151. https://doi.org/10.1358/mf.1999.21.2.529241
6. Zuo, J., Du, L., Li, M., Liu, B., Zhu, W., & Jin, Y. (2014). Transdermal enhancement effect and mechanism of iontophoresis for non-steroidal anti-inflammatory drugs. International Journal of Pharmaceutics, 466(1-2), 76–82. https://doi.org/10.1016/j.ijpharm.2014.03.013
7. Kumar, M. G., & Lin, S. (2008). Transdermal iontophoresis: Impact on skin integrity as evaluated by various methods. Critical Reviews in Therapeutic Drug Carrier Systems, 25(4), 381–401.
8. Singh, P., & Maibach, H. I. (1994). Iontophoresis in drug delivery: Basic principles and applications. Critical Reviews in Therapeutic Drug Carrier Systems, 11(2-3), 161–213. https://pubmed.ncbi.nlm.nih.gov/7600587/
9. Singh, J., & Roberts, M. S. (1989). Transdermal delivery of drugs by iontophoresis: A review. Drug Design and Delivery, 4(1), 1–12. https://pubmed.ncbi.nlm.nih.gov/2673280/
10. Karpiński, T. M. (2018). Selected medicines used in iontophoresis. Pharmaceutics, 10(4), 204. https://doi.org/10.3390/pharmaceutics10040204
11. Dixit, N., Bali, V., Baboota, S., Ahuja, A., & Ali, J. (2007). Iontophoresis – An approach for controlled drug delivery: A review. Current Drug Delivery, 4(1), 1–10. https://doi.org/10.2174/1567201810704010001
12. Baktir, S., Ozdincler, A. R., Mutlu, E. K., & Bilsel, K. (2019). The short-term effectiveness of low-level laser, phonophoresis, and iontophoresis in patients with lateral epicondylosis. Journal of Hand Therapy, 32(4), 417-425. https://doi.org/10.1016/j.jht.2018.01.002
13. Lark, M. R., & Gangarosa, L. P. (1990). Iontophoresis: An effective modality for treatment of inflammatory disorders. Cranio, 8(2), 108-119. https://doi.org/10.1080/08869634.1990.11678305
14. Che, X., Wang, L., Yuan, Y., Gao, Y., Wang, Q., Yang, Y., & Li, S. (2012). A novel method to enhance transdermal iontophoresis delivery. International Journal of Pharmaceutics, 428(1-2), 68-75. https://doi.org/10.1016/j.ijpharm.2012.02.039
15. Kalia, Y. N., Naik, A., Garrison, J., & Guy, R. H. (2004). Iontophoretic drug delivery. Advanced Drug Delivery Reviews, 56(5), 619–658. https://doi.org/10.1016/j.addr.2003.10.026
16. Eslami, S., Tahmasbi, F., Rahimi-Mamaghani, A., Sanaie, S., Bettocchi, C., Sedigh, O., & Soleimanzadeh, F. (2025). Investigating iontophoresis as a therapeutic approach: A systematic review. Sexual Medicine Reviews, 13(1), 41-51. https://doi.org/10.1093/sxmrev/qeae058
17. Pontrelli, G., Lauricella, M., Ferreira, J., & Pena, G. (2016). Iontophoretic transdermal drug delivery: A multi-layered approach. Mathematical Biosciences.
18. Machado, N., Callegaro, C., Christoffolete, M., & Martinho, H. (2019). Tuning transdermal transport by application of electric field. Journal of Molecular Modeling.
19. Anatychuk, L. I., Kushneryk, L. Ya., & Seredyuk, O. I. (2005). Device for thermoreflexotherapy. Ukrainian Patent No. 8405 UA. State Intellectual Property Service of Ukraine.
20. Anatychuk, L. I., Kushneryk, L. Ya., & Rozver, Yu. Yu. (2005). Device for treatment of hematomas. Ukrainian Patent No. 5701 UA. State Intellectual Property Service of Ukraine.
21. Saringer, J. H. (1999). Device for producing cold therapy (U.S. Patent No. US5895418A). U.S. Patent and Trademark Office.
22. Anatychuk, L. I., Kobylianskyi, R. R., Fedoriv, R. V., & Konstantynovych, I. A. (2023). On the prospects of using thermoelectric cooling for the treatment of cardiac arrhythmia. Journal of Thermoelectricity, (2), 5–17. https://doi.org/10.63527/1607-8829-2023-2-5-17
23. Kobylianskyi, R. R., Zadorozhnyi, O. S., Umanets, M. M., Pasechnikova, N. V., Rozver, Y. Y., & Babich, A. O. (2024). Computer simulation of a thermoelectric device for controlling the temperature of irrigation fluid during ophthalmological operations. Journal of Thermoelectricity, (1–2), 61–71. https://doi.org/10.63527/1607-8829-2024-1-2-61-71
24. Kobylianskyi, R. R., Lysko, V. V., Pasechnikova, N. V., Umanets, M. M., Zadorozhnyi, O. S., Rozver, Y. Y., & Babich, A. O. (2025). Application of thermoelectric cooling and heating to control the temperature of irrigation fluid in ophthalmic surgery, 26(1), 151–157. DOI:10.15330/pcss.26.1.151-157
25. Anatychuk, L.I., Vikhor, L.M., Kobylianskyi, R.R., Kadeniuk, T.Y. Computer simulation and optimization of the dynamic operating modes of thermoelectric device for treatment of skin diseases. Journal of Thermoelectricity. 2017, (2), 46–59.
26. Anatychuk, L.I., Kobylianskyi, R.R., Kadenyuk, T.Y. Computer simulation of local thermal effect on human skin. Journal of Thermoelectricity. 2017, (1), 62–70.
27. Anatychuk, L.I., Vikhor, L.M., Kobylianskyi, R.R., Kadeniuk, T.Y., Zvarych, O.V. Computer simulation and optimization of the dynamic operating modes of thermoelectric reflexotherapy device. Journal of Thermoelectricity. 2017, (3), 65–74.
28. Anatychuk, L.I., Kobylianskyi, R.R., Fedoriv, R.V. Computer simulation of human skin cryodestruction process during thermoelectric cooling. 2019, (2), 21–35.
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