The Role of Thermoelectricity in Biological Research and Medical Applications

Authors

DOI:

https://doi.org/10.63527/1607-8829-2026-3-63-81

Keywords:

Thermoelectricity, biology, medicine

Abstract

The article considers the use of thermoelectric phenomena of the Peltier and Seebeck effects and devices based on them as a highly effective tool for solving current problems in the field of Life Sciences. Considerable attention is paid to the advantages of thermoelectric cooling, heating and highly sensitive thermometry due to the absence of moving parts, due to the high accuracy of temperature maintenance and compactness of the devices.

References

1. Enescu, D. (2024). Innovations in thermoelectric technology: From materials to applications. Energies, 17(7), 1692. https://doi.org/10.3390/en17071692

2. Adair, R., Astumian, R., & Weaver, J. (1998). Detection of weak electric fields by sharks, rays, and skates. Chaos: An Interdisciplinary Journal of Nonlinear Science, 8(3), 576–587. https://doi.org/10.1063/1.166339

3. EvenSkyn. (n.d.). The biochemistry of collagen: Implications for microcurrent facials. https://www.evenskyn.com/blogs/skin-beautyarticles/biochemistry-collagen-microcurrent-facials

4. Athenstaedt, H. (1974). Pyroelectric and piezoelectric properties of vertebrates. Annals of the New York Academy of Sciences, 238(1), 68–94. https://doi.org/10.1111/j.1749-6632.1974.tb26780.x

5. Zhang, Z., Wang, Z., Li, X., Zheng, Y., & Yang, Z. (2025). Design and Manufacturing of Piezoelectric Biomaterials for Bioelectronics and Biomedical Applications. Chemical Reviews, 125(20), 9875–9929. https://doi.org/10.1021/acs.chemrev.5c00399

6. Ioana Visan, A., Negut, I., & Hapenciuc, C. (2025). Recent Advances in Thermoelectric Materials for Biomedical Applications: Energy Harvesting and Wearables. IntechOpen. doi: 10.5772/intechopen.1009793.

7. ZJCX Tech. (2025, March 12). How Peltier thermoelectric coolers enhance PCR thermal cycling. https://www.zjcxtech.com/how-peltier-thermoelectric-coolers-enhance-pcr-thermal-cycling/

8. Kridelbaugh, D. (2024, January 16). Understanding thermal cyclers: An introduction and overview. Lab Manager. https://www.labmanager.com/understanding-thermal-cyclers-an-introduction-and-overview-31635

9. Rho, N. K. (2022). Revisiting the role of local cryotherapy for acne treatment: A review and update. Journal of Clinical Medicine, 12(1), Article 26. https://doi.org/10.3390/jcm12010026

10. Zabilo, Y., Shlykov, V., & Vovianko, S. (2023). Using the Peltier effect for intravascular cooling of donor organs. Biomedical Engineering and Technology, (10). https://doi.org/10.20535/2617-8974.2023.10.281415

11. Sun, D., Han, X., Wang, H., Shen, L., Gao, C., Niu, J., Liu, X., Ye, J., & Yao, Q. (2024). Investigation on the linear cooling method of microfluidic chip based on thermoelectric cooler. Energy, 309, 132933. https://doi.org/10.1016/j.energy.2024.132933

12. Havryliuk, M., Kobylianskyi, R., & Konstantynovych, I. (2026). Thermoelectric Device for Iontophoresis. Journal of Thermoelectricity, (1), 84–92. https://doi.org/10.63527/1607-8829-2026-1-84-92.

13. Kordani, N., Rahmani, A., & Hasanzadeh, R. P. (2018). Smart Portable Cryotherapy System Involving Controlled Thermoelectric Cooling Modules for Medical Applications. IIUM Engineering Journal, 19(1), 117–128. https://doi.org/10.31436/iiumej.v19i1.791

14. Xu, Q., Deng, B., Wang, Y., Liu, W., & Chen, G. (2023). Small, affordable, ultra-low-temperature vapor-compression and thermoelectric hybrid freezer for clinical applications. Cell Reports Physical Science, 4(12), 101735. https://doi.org/10.1016/j.xcrp.2023.101735

15. de Albuquerque Neto, F. R., de Oliveira, J. E. F., Dourado da Silva, R. G., Tomás, A. C. C., Ochoa, A. A. V., da Costa, J. Â. P., de Souza, A. C., & Michima, P. S. A. (2025). Statistical Analysis of Temperature Sensors Applied to a Biological Material Transport System: Challenges, Discrepancies, and a Proposed Monitoring Methodology. Processes, 13(6), 1904. https://doi.org/10.3390/pr13061904

16. Salim, B., Alsalam, B., & Al Rifaie, M. (2023, June 19). An experimental investigation of a portable solar thermoelectric fridge for storing some vaccines. Northern Technical University. https://doi.org/10.22541/au.168717639.93235175/v1

17. Nadimuthu, L. P. R., Victor, K., Bajaj, M., Blazek, V., & Prokop, L. (2025). Solar-thermoelectric mobile storage system integrated with electric vehicles for reducing postharvest and microbial losses in agro produce transportation. Scientific Reports, 15, 15522. https://doi.org/10.1038/s41598-025-00501-9

18. Daniol, M., Boehler, L., Sroka, R., & Keller, A. (2020). Modeling and Implementation of TEG-Based Energy Harvesting System for Steam Sterilization Surveillance Sensor Node. Sensors, 20(21), 6338. https://doi.org/10.3390/s20216338

19. Gemma, A., Tabatabaei, F., Drechsler, U., Gotsmann, B., & Lörtscher, E. (2023). Full thermoelectric characterization of a single molecule. Nature Communications, 14(1), 3868. https://doi.org/10.1038/s41467-023-39368-7

20. Li, Y., Xiang, L., Palma, J., Asai, Y., & Tao, N. (2016). Thermoelectric effect and its dependence on molecular length and sequence in single DNA molecules. Nature Communications, 7(1), 11294. https://doi.org/10.1038/ncomms11294

21. Kridelbaugh, D. (2024, January 16). Understanding thermal cyclers: An introduction and overview. Lab Manager. https://www.labmanager.com/understanding-thermal-cyclers-an-introduction-and-overview-31635

22. Zimbovskaya, N. A. (2024). Thermoelectric properties of Marcus molecular junctions [Preprint]. arXiv. https://arxiv.org/abs/2401.07099

23. He, P., Jang, J., Kang, H., & Yoon, H. J. (2025). Thermoelectricity in molecular tunnel junctions. Chemical Reviews, 125(5), 2953–3004. https://doi.org/10.1021/acs.chemrev.4c00886

24. Fang, C., Li, Y., Wang, S., Liang, M., Yan, C., Liu, J., & Hong, W. (2025). Thermoelectric and thermal properties of molecular junctions: mechanisms, characterization methods and applications. Chemical Communications, 61(33), 4447–4464. https://doi.org/10.1039/D4CC06822J

25. Gonzalez-Casal, S., Jouclas, R., Arbouch, I., Geerts, Y., van Dyck, C., Cornil, J., & Vuillaume, D. (2024). Thermoelectric properties of benzothieno-benzothiophene self-assembled monolayers in molecular junctions [Preprint]. arXiv. https://doi.org/10.48550/arXiv.2409.12596

26. Gonzalez-Casal, S., Jouclas, R., Arbouch, I., Geerts, Y., van Dyck, C., Cornil, J., & Vuillaume, D. (2025). Electronic and thermoelectric properties of molecular junctions incorporating organometallic complexes: Implications for thermoelectric energy conversion. ACS Applied Nano Materials, 8(28), 14261–14280. https://doi.org/10.1021/acsanm.5c02362

27. Santos Almeida, J., Gonzalez Casal, S., Al Sabea, H., Barth, V., Mitra, G., Delmas, V., Guérin, D., Galangau, O., Tiwary, T., Roisnel, T., Dorcet, V., Norel, L., Van Dyck, C., Scheer, E., Vuillaume, D., Cornil, J., Rigaut, S., & Costuas, K. (2025). Electronic and thermoelectric properties of molecular junctions incorporating organometallic complexes: Implications for thermoelectric energy conversion. ACS Applied Nano Materials, 8(28), 14261–14280. https://doi.org/10.1021/acsanm.5c02362

28. Jang, J., Jo, J. W., Ohto, T., & Yoon, H. J. (2024). Seebeck effect in molecular wires facilitating long-range transport. Journal of the American Chemical Society. https://doi.org/10.1021/acs.jacs.4c02753

29. Park, S., Jang, J., Tanaka, Y., & Yoon, H. J. (2022). High Seebeck coefficient achieved by multinuclear organometallic molecular junctions. Nano Letters, 22(23), 9693–9699. https://doi.org/10.1021/acs.nanolett.2c03974

30. Jia, S., Ma, H., Gao, S., Yang, L., & Sun, Q. (2024). Thermoelectric materials and devices for advanced biomedical applications. Small. Advance online publication. https://doi.org/10.1002/smll.202405019

31. Baskaran, P., & Rajasekar, M. (2025). Recent progress in thermoelectric devices and applications. Chemical Engineering Journal, 506, 159929. https://doi.org/10.1016/j.cej.2025.159929

32. Beretta, D., Neophytou, N., Hodges, J. M., Kanatzidis, M. G., Narducci, D., Martín-González, M. S., Beekman, M., Balke, B., Cerretti, G., Tremel, W., Zevalkink, A., Hofmann, A., Müller, C., Dörling, B., Campoy-Quiles, M., & Caironi, M. (2019). Thermoelectrics: From history, a window to the future. Materials Science and Engineering: R: Reports, 138, 100501. https://doi.org/10.1016/j.mser.2018.09.0013.

33. Choi, Y., Kim, J. Y., Kang, B. C., & Kim, H. (2025). Perspectives on hydrogel-based ionic thermoelectrics: From mechanistic insights to wearable applications of thermo-diffusive ionic materials. Energy Materials, 5, 500106. http://dx.doi.org/10.20517/energymater.2025.50

34. Xin, J., Jiang, Y., Chen, J., Sullivan, J., & Li, J. (2021). Inorganic thermoelectric fibers: A review of materials, fabrication methods, and applications. Sensors, 21(10), 3437. https://doi.org/10.3390/s21103437.

35. Hu, B., Li, J., Jiang, Y., Xin, J., & Li, J. (2022). Thermoelectrics for medical applications: Progress, challenges, and perspectives. Chemical Engineering Journal, 437, 135268. https://doi.org/10.1016/j.cej.2022.135268

36. Kwon, C., Myoung, J., Tyagi, K., Kim, S. J., Ko, Y., Choi, J., & Cho, S. P. (2024). Stretchable Ag2Se thermoelectric fabric with simple and nonthermal fabrication for wearable electronics. Small Science, 4(11), 2400230. https://doi.org/10.1002/smsc.202400230

37. Ma, H., Jia, S., Gao, S., Yang, L., & Sun, Q. (2024). Flexible Ag2Se thermoelectric films enable the multifunctional thermal perception in electronic skins. ACS Applied Materials & Interfaces, 16(6), 7453–7462. https://doi.org/10.1021/acsami.3c16645

38. Rao, Y., Huang, L., Yan, Y., & Zhang, K. (2024). Fabrication and characterization of a thermoelectric generator with high aspect ratio thermolegs for electrically active implants. Advanced Materials Technologies, 9(1), 2301157. https://doi.org/10.1002/admt.202301157

39. Kobylianskyi, R., Vikhor, L., Fedoriv, R., & Izvak, Y. (2024). Design of a multi-stage thermoelectric cooler for a human heart ablation device. Journal of Thermoelectricity, (4), 5–13. https://doi.org/10.63527/1607-8829-2024-4-5-13

40. Singh, S., & Melnik, R. (2020). Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions. Electromagnetic Biology and Medicine, 39(2), 49–88. https://doi.org/10.1080/15368378.2020.1741383

41. Kobylianskyi, R., Ivashchuk, O., Bodiaka, V., & Fedoriv, R. (2025). Computer optimization of the working tool for a thermoelectric cryodestruction device. Journal of Thermoelectricity, (1), 81–100. https://doi.org/10.63527/1607-8829-2025-1-81-100

42. Kobylianskyi, R., Lysko, V., Fedoriv, R., Ivashchuk, O., Bodiaka, V., & Malyshevskyi, I. (2025). Computer simulation of cyclic temperature effect on biological tissue during the destruction of oncologic tumors. Journal of Thermoelectricity, (2), 85–96.

43. Kobylianskyi, R. R., Prybyla, A. V., Konstantynovych, I. A., & Boychuk, V. V. (2022). Results of experimental research on thermoelectric medical heat flow sensors. Journal of Thermoelectricity, (3-4), 68–81. https://doi.org/10.63527/1607-8829-2022-3-4-68-81

44. Min, Yang & Li, Chang & Zhang, Y B & Wang, Yaogang & Li, Benkai & Dongzhou, Jia & Hou, Yali & Li, Runze. (2017). Research on microscale skull grinding temperature field under different cooling conditions.Applied Thermal Engineering. 126. 10.1016/j.applthermaleng.2017.07.183

45. Ganesan, V. V., Enam, S. F., & Jain, A. (2026). Thermal characterization of microwires for hypothermia-based glioblastoma treatment. International Journal of Thermal Sciences, 220, 110246. https://doi.org/10.1016/j.ijthermalsci.2025.110246

46. Hong, J. M., Choi, E. S., & Park, S. Y. (2022). Selective brain cooling: A new horizon of neuroprotection. Frontiers in Neurology, 13, 873165. https://doi.org/10.3389/fneur.2022.873165

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Published

30.09.2026

How to Cite

Mykytyuk, O., Slypaniuk, O., Mykytiuk, P., & Pishak, O. (2026). The Role of Thermoelectricity in Biological Research and Medical Applications. Journal of Thermoelectricity, (3), 63–81. https://doi.org/10.63527/1607-8829-2026-3-63-81

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